SQL Server replace, remove all after certain character

Use LEFT combined with CHARINDEX:

UPDATE MyTable
SET MyText = LEFT(MyText, CHARINDEX(';', MyText) - 1)
WHERE CHARINDEX(';', MyText) > 0

Note that the WHERE clause skips updating rows in which there is no semicolon.

Here is some code to verify the SQL above works:

declare @MyTable table ([id] int primary key clustered, MyText varchar(100))
insert into @MyTable ([id], MyText)
select 1, 'some text; some more text'
union all select 2, 'text again; even more text'
union all select 3, 'text without a semicolon'
union all select 4, null -- test NULLs
union all select 5, '' -- test empty string
union all select 6, 'test 3 semicolons; second part; third part;'
union all select 7, ';' -- test semicolon by itself    

UPDATE @MyTable
SET MyText = LEFT(MyText, CHARINDEX(';', MyText) - 1)
WHERE CHARINDEX(';', MyText) > 0

select * from @MyTable

I get the following results:

id MyText
-- -------------------------
1  some text
2  text again
3  text without a semicolon
4  NULL
5        (empty string)
6  test 3 semicolons
7        (empty string)

Ref: https://stackoverflow.com/questions/1668014/sql-server-replace-remove-all-after-certain-character